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乳腺癌风险因素

2023 年 10 月 10 日

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2 分钟阅读

Breast Cancer Risk Factors

Breast Cancer is one of the scariest and most frequently diagnosed cancers among women in Malaysia as well as worldwide. In Malaysia, one in 27 women will develop breast cancer in their lifetimes.

Therefore, there is a great need to spread awareness of how risk factors and regular screenings come into play for early detection and prompt treatment to improve survival rates of breast cancer patients.

Risk Factors simply mean factors that increase our chance of developing Breast Cancer – which can be divided into two types: non-modifiable and modifiable risk factors.

Non-modifiable risk factors are factors that cannot be changed – it includes gender, family history of breast cancer and being a carrier of the BRCA1 and BRCA2 gene mutation. Hitting puberty early (<12 years old) and menopause later in life (>55 years old) further increases risks of developing Breast Cancer. Early menarche and late menopause cause prolonged lifetime exposure to endogenous ovarian hormones (i.e: estrogen). The longer the exposure, the higher the Breast Cancer risk.

Modifiable risks down to lifestyle choices such as sedentary habits, alcohol consumption, smoking and even long-term intake of exogenous hormones in the form of Oral Contraceptive Pills or Hormone Replacement Therapy. Not bearing children, first full term pregnancy after the age of 30 as well as no breast-feeding, increases the risk further.

Most of us are aware that excessive alcohol consumption and smoking increase risk of not only Breast Cancer but various other cancers. Alcohol increases the level of estrogen and other hormones associated with hormone-receptor-positive breast cancers. Alcohol may also increase breast cancer risks by damaging DNA in cells. Hence, limiting the amount of alcohol consumption is important.

Non-modifiable risks cannot be changed. However, risks may be lowered for some patients; for example, prophylactic mastectomy can be performed to lower breast cancer risks in BRCA gene mutation carriers. In terms of modifiable risk factors, leading a healthy lifestyle, regular exercise and maintaining a healthy weight, will not only reduce risks of Breast Cancer but also reduce risks of recurrence in survivors.
 
Although family history of breast cancer is a significant risk factor, only five percent to 10 percent of Breast Cancer cases are inherited. The remaining 90 to 95 percent of cases are sporadic. This simply means that if we do not have a family member with breast cancer, we are not spared from the disease. Therefore, it is essential for women to participate in Breast Cancer screening programmes and perform mammograms or ultrasound as per recommendation so that immediate action may be taken should they be diagnosed.

Thanks to Breast Cancer research over the years, treatment has come a long way; significantly improving survival and prognosis especially for patients with early stage Breast Cancer. There has been advancement in surgical techniques as well as neoadjuvant/adjuvant treatment, which are now widely available. *A neoadjuvant treatment shrinks tumors or stops cancer from spreading before any surgery, to make the surgery less invasive. Adjuvant treatment is done after surgery to kill remaining cancer cells and lower chances of recurrence.

Most of us are aware that excessive alcohol consumption and smoking increase risk of not only Breast Cancer but various other cancers. Alcohol increases the level of estrogen and other hormones associated with hormone-receptor-positive breast cancers. Alcohol may also increase breast cancer risks by damaging DNA in cells. Hence, limiting the amount of alcohol consumption is important.

Non-modifiable risks cannot be changed. However, risks may be lowered for some patients; for example, prophylactic mastectomy can be performed to lower breast cancer risks in BRCA gene mutation carriers. In terms of modifiable risk factors, leading a healthy lifestyle, regular exercise and maintaining a healthy weight, will not only reduce risks of Breast Cancer but also reduce risks of recurrence in survivors.

In the Asian region, many patients seek treatment only during the later stages of cancer. The challenge that we face is beliefs. Large numbers of patients strongly believe in alternative medicine as the mainstay for cure of breast cancer. This causes delays in them coming forward for treatment. The problem of stigma is also common, whereby it creates a significant barrier to medical care.

It is only with the eradication of such beliefs that we can see an increase in early detection and improvement in the survival rates of breast cancer.

Indeed, early detection really does save lives.

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2023 年 10 月 10 日

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2 分钟阅读

Breast Cancer Risk Factors

Dr. Kiran Kaur D/o Amer Singh

General Surgery

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